Trepiline 10 mg, 25 mg Tablets
PDF Leaflet Revision Date: 28 July 2017
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of depression in patients 18 years and older.
Dosage (summary)
Initial: 75-150 mg daily; Maintenance: 50-100 mg daily.
Onset of Action / Duration
Onset: 6 hours, Duration: 9-25 hours
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Not established; contraindicated in pregnancy and lactation.
Key Drug Interactions
- MAOIs
- SSRIs
- CNS depressants
- Antihypertensives
Contraindications
- Hypersensitivity
- Myocardial infarction
- Concurrent MAOIs
- Pregnancy
- Lactation
- Children under 18
Common side effects
- Drowsiness
- Dry mouth
- Constipation
- Blurred vision
Counselling Points
- Avoid driving until effects are known
- Monitor for suicidal thoughts
- Do not combine with alcohol or CNS depressants
Serious warnings
- Suicidal tendencies
- Cardiac disease caution
- Anticholinergic effects
Important Disclaimer
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