Zofran 4mg & 8mg (Tablets and Injection)
PDF Leaflet Revision Date: 7 December 2012
Clinical Summary
Quick overview from the medicine insert
Indication
Management of nausea and vomiting induced by chemotherapy and radiotherapy.
Dosage (summary)
Adults: 8 mg IV/IM before treatment, then 8 mg orally every 12 hours. Max 8 mg/day in hepatic impairment.
Onset of Action / Duration
Onset: 30 mins, Duration: 6-8 hours
Special Populations
- Elderly
- Hepatic impairment
Pregnancy & Breastfeeding
Contraindicated in pregnancy; avoid breastfeeding.
Key Drug Interactions
- Apomorphine
- CYP3A4 inducers (e.g., phenytoin)
- Tramadol
Contraindications
- Hypersensitivity
- Congenital long QT syndrome
- Pregnancy for post-operative use
Common side effects
- Headache
- Constipation
- Dizziness
- Hypotension
Counselling Points
- Monitor for QT prolongation
- Avoid in patients with electrolyte abnormalities
- Do not mix with other medications for infusion
Serious warnings
- QT prolongation
- Hypersensitivity reactions
- Caution in hepatic impairment
Important Disclaimer
The Zofran 4mg & 8mg (Tablets and Injection) professional information leaflet below is the property of Novartis South Africa and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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