Bupropion Accord 300 mg Tablet
PDF Leaflet Revision Date: 25 March 2025
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of depression as per DSM IV criteria.
Dosage (summary)
Initial: 150 mg once daily; may increase to 300 mg once daily after 24 hours.
Special Populations
- Renal impairment
- Hepatic impairment
- Elderly
Pregnancy & Breastfeeding
Not established; potential risk of congenital malformations. Avoid breastfeeding.
Key Drug Interactions
- CYP2B6 inhibitors
- MAOIs
- Alcohol
Contraindications
- Hypersensitivity to bupropion
- Seizure disorder
- Eating disorders
- Patients under 18 years
- Monoamine oxidase inhibitors
Common side effects
- Insomnia
- Agitation
- Dry mouth
- Increased blood pressure
- Seizures
Counselling Points
- Monitor for worsening depression or suicidal thoughts.
- Avoid alcohol.
- Do not crush or chew tablets.
Serious warnings
- Risk of seizures
- Suicidal ideation
- Hypersensitivity reactions
Important Disclaimer
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