Cabxel 60 Mg/1.5 Ml Iv 60 mg Concentrate for solution for infusion
PDF Leaflet Revision Date: 27 June 2023
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of hormone refractory metastatic prostate cancer.
Dosage (summary)
25 mg/mu00b2 IV infusion every 3 weeks with daily prednisone 10 mg.
Special Populations
- Elderly u2265 65 years
- Hepatic impairment
- Renal impairment
Pregnancy & Breastfeeding
Not recommended during pregnancy or breastfeeding.
Key Drug Interactions
- Strong CYP3A inhibitors
- Strong CYP3A inducers
Contraindications
- Hypersensitivity to cabazitaxel
- Neutrophil counts u2264 1,500/mmu00b3
- Hepatic impairment
- Concomitant yellow fever vaccination
Common side effects
- Neutropenia
- Diarrhoea
- Fatigue
- Hypersensitivity
Counselling Points
- Premedicate to reduce hypersensitivity risk
- Avoid live vaccines
- Monitor for signs of neuropathy
Serious warnings
- Neutropenia monitoring required
- Severe hypersensitivity reactions possible
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