Onbort 1 Mg/0.4 Ml, 2.5 Mg/Ml & 3.5 Mg/1.4 Ml 1 mg/0.4 ml, 2.5 mg/ml & 3.5 mg/1.4 ml Solution for Injection.
PDF Leaflet Revision Date: 22 July 2025
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of multiple myeloma and mantle cell lymphoma.
Dosage (summary)
1.3 mg/mu00b2 twice weekly for two weeks, followed by a rest period.
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Not recommended during pregnancy; safety in lactation not established.
Key Drug Interactions
- CYP3A4 inhibitors
- CYP3A4 inducers
- Narcotics
Contraindications
- Hypersensitivity
- Acute diffuse infiltrative pulmonary disease
Common side effects
- Nausea
- Diarrhoea
- Constipation
- Fatigue
- Thrombocytopenia
Counselling Points
- Use effective contraception during treatment.
- Avoid driving if experiencing dizziness or hypotension.
Serious warnings
- Inadvertent intrathecal administration can be fatal.
- Monitor for neuropathy and hypotension.
Important Disclaimer
The Onbort 1 Mg/0.4 Ml, 2.5 Mg/Ml & 3.5 Mg/1.4 Ml 1 mg/0.4 ml, 2.5 mg/ml & 3.5 mg/1.4 ml Solution for Injection. professional information leaflet below is the property of Hetero Drugs South Africa and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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