Carbilev 25mg/250mg and 25 mg/250 mg Tablets.
PDF Leaflet Revision Date: 24 December 2020
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of Parkinsonu2019s disease and syndrome.
Dosage (summary)
Start with 1 tablet of CARBILEV 25/100 three times daily; max 8 tablets daily.
Special Populations
- Renal impairment
- Hepatic impairment
- Cardiovascular disease
- Paediatric population
Pregnancy & Breastfeeding
Not recommended in pregnancy; may inhibit lactation.
Key Drug Interactions
- MAO inhibitors
- Antihypertensives
- Antidepressants
- Anticholinergics
- Iron
Contraindications
- Hypersensitivity to carbidopa/levodopa
- Severe psychoses
- Closed-angle glaucoma
- History of malignant melanoma
Common side effects
- Dyskinesias
- Nausea
- Dizziness
- Somnolence
Counselling Points
- Monitor for sudden sleep onset
- Avoid driving until effects are known
- Gradual dosage reduction when discontinuing
Serious warnings
- Risk of neuroleptic malignant syndrome
- Impulse control disorders
- Dopamine Dysregulation Syndrome
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