Doxorubicin Liposomal 20 Mg/10 Ml & 50 Mg/25 Ml Accord 20 mg/10 ml & 50 mg/25 ml Concentrate for solution for infusion
Clinical Summary
Quick overview from the medicine insert
Indication
Metastatic breast cancer, advanced ovarian cancer, multiple myeloma, AIDS-related Kaposi's sarcoma.
Dosage (summary)
50 mg/mu00b2 every 4 weeks for breast/ovarian cancer; 30 mg/mu00b2 on day 4 of bortezomib regimen; 20 mg/mu00b2 every 2-3 weeks for AIDS-KS.
Special Populations
- Hepatic impairment
- Renal impairment
- Elderly patients
Pregnancy & Breastfeeding
Contraindicated in pregnancy and breastfeeding.
Key Drug Interactions
- Caution with other cytotoxic agents
- May enhance toxicity of other anti-cancer therapies
Contraindications
- Hypersensitivity to doxorubicin
- Pregnancy
- Breastfeeding
- Patients <18 years
Common side effects
- Neutropenia
- Nausea
- Fatigue
- Stomatitis
- Palmar-plantar erythrodysaesthesia
Counselling Points
- Avoid pregnancy during treatment
- Monitor for infusion reactions
- Report any severe side effects immediately
Serious warnings
- Cardiac toxicity
- Myelosuppression
- Infusion reactions
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