Adco-Lamivudine Solution
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of HIV-1 infection in combination with other antiretroviral agents.
Dosage (summary)
The recommended dose for adults and children over 12 years is 300 mg once daily or 150 mg twice daily. For children aged 3 months to 12 years, the dose is based on body weight.
Onset of Action / Duration
Lamivudine has a rapid onset of action, with antiviral effects observed within a few days of initiation. However, the full therapeutic effect may take several weeks.
Special Populations
- Renal impairment
- Hepatic impairment
- Elderly patients
Pregnancy & Breastfeeding
Lamivudine is classified as Category B3 for pregnancy. It is generally considered safe to use during pregnancy, but should be used only if clearly needed. It is excreted in breast milk; breastfeeding is not recommended for HIV-infected mothers.
Key Drug Interactions
- Zidovudine may increase the risk of hematologic toxicity when used with lamivudine.
- Concurrent use with other antiretroviral agents may require dose adjustments.
Contraindications
- Hypersensitivity to lamivudine or any component of the formulation.
- Severe hepatic impairment.
Common side effects
- Headache
- Nausea
- Diarrhea
- Fatigue
- Liver enzyme elevation
Counselling Points
- Advise patients to take the medication exactly as prescribed.
- Inform patients about the importance of adherence to therapy to prevent resistance.
- Educate about potential side effects and when to seek medical attention.
Serious warnings
- Risk of lactic acidosis, especially in patients with hepatic disease.
- Monitor for signs of pancreatitis.
- Discontinuation of therapy may lead to acute exacerbation of hepatitis B in co-infected patients.
Important Disclaimer
The Adco-Lamivudine Solution professional information leaflet below is the property of Adcock Ingram and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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