Abitrexate Tablets

Indication

Treatment of certain types of cancer, severe psoriasis, and rheumatoid arthritis.

Dosage (summary)

Initial dose varies based on condition; typically, 7.5 mg to 25 mg once weekly for rheumatoid arthritis, and higher doses for cancer treatment.

Onset of Action / Duration

Onset of action may take several weeks; full therapeutic effect may take 6 to 8 weeks.

Special Populations

• Elderly patients may have increased sensitivity.
• Patients with renal impairment require dose adjustments.
• Patients with hepatic impairment should be closely monitored.

Pregnancy & Breastfeeding

Methotrexate is contraindicated in pregnancy due to risk of fetal harm; it is also excreted in breast milk and should be avoided during lactation.

Key Drug Interactions

• NSAIDs may increase the risk of methotrexate toxicity.
• Penicillins can decrease renal clearance of methotrexate.
• Live vaccines should be avoided during treatment.

Contraindications

• Pregnancy and lactation.
• Severe renal impairment.
• Active infections.
• Hypersensitivity to methotrexate.

Common side effects

• Nausea and vomiting.
• Mucositis.
• Hepatotoxicity.
• Bone marrow suppression.
• Pulmonary toxicity.

Counselling Points

• Advise patients to maintain adequate hydration.
• Instruct patients to report any signs of infection or unusual bleeding.
• Discuss the importance of regular blood tests to monitor liver function and blood counts.