Topzole Range 20 mg, 40 mg Enteric-coated tablets
PDF Leaflet Revision Date: 20 February 2026
Clinical Summary
Quick overview from the medicine insert
Indication
Short-term treatment of duodenal and gastric ulcers, reflux oesophagitis, and Zollinger-Ellison Syndrome.
Dosage (summary)
40 mg once daily for ulcers; 20 mg once daily for mild reflux disease.
Special Populations
- Elderly
- Impaired renal function
- Mild to moderate hepatic impairment
Pregnancy & Breastfeeding
Safety in pregnancy and lactation not established.
Key Drug Interactions
- HIV protease inhibitors
- Methotrexate
- Warfarin
Contraindications
- Hypersensitivity to pantoprazole
- Severe liver impairment
- Children
Common side effects
- Headache
- Dizziness
- Nausea
- Diarrhoea
Counselling Points
- Take before or during breakfast
- Monitor for severe skin reactions
- Report persistent gastrointestinal symptoms
Serious warnings
- Increased risk of fractures
- Clostridium difficile-associated diarrhoea
- Hypomagnesaemia
Important Disclaimer
The Topzole Range 20 mg, 40 mg Enteric-coated tablets professional information leaflet below is the property of Takeda and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
Healthcare Professionals Only
This content is for registered healthcare professionals
Sign in or create a free account to read the full package insert.
Free for HPCSA-registered professionals. Powered by Medinsert.
