B Braun Propofol 1 % (10 mg/ml) Injection

Indication

Induction and maintenance of general anesthesia; sedation for mechanically ventilated adults and procedural sedation.

Dosage (summary)

Administered intravenously; typical induction dose is 1-2.5 mg/kg, maintenance dose is 4-12 mg/kg/hour depending on the clinical situation.

Onset of Action / Duration

Onset of action is within 30 seconds; duration of effect is approximately 5-10 minutes.

Special Populations

• Elderly patients may require reduced doses.
• Patients with hepatic impairment may require dose adjustments.
• Patients with cardiovascular instability should be monitored closely.

Pregnancy & Breastfeeding

Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Propofol is excreted in breast milk; caution is advised when administering to nursing mothers.

Key Drug Interactions

• Caution with other CNS depressants (e.g., opioids, benzodiazepines) as they may enhance sedative effects.
• Potential interaction with drugs that affect liver enzymes (e.g., CYP450 inducers/inhibitors).

Contraindications

• Hypersensitivity to propofol or any of its components.
• Patients with a history of egg or soy allergy (contains soybean oil).
• Severe cardiovascular instability.

Common side effects

• Hypotension
• Respiratory depression
• Bradycardia
• Injection site pain
• Allergic reactions

Counselling Points

• Inform patients about the potential for drowsiness and advise against driving or operating machinery after administration.
• Discuss the importance of informing healthcare providers about any allergies, especially to eggs or soy.
• Advise patients to report any unusual symptoms or side effects immediately.