3 TC Tablet and Solution

Indication

Treatment of HIV-1 infection in combination with other antiretroviral agents.

Dosage (summary)

The recommended dose for adults and adolescents is 150 mg twice daily or 300 mg once daily. For children, the dose is based on body weight.

Onset of Action / Duration

Onset of action is typically within 1-2 weeks, with optimal viral suppression observed over several weeks.

Special Populations

• Renal impairment
• Hepatic impairment
• Elderly patients

Pregnancy & Breastfeeding

Lamivudine is classified as Category B3. It is generally considered safe during pregnancy, but should be used only if clearly needed. It is excreted in breast milk; caution is advised.

Key Drug Interactions

• Zidovudine may increase the risk of hematologic toxicity when used with Lamivudine.
• Other antiretroviral agents may have additive effects.

Contraindications

• Hypersensitivity to Lamivudine or any component of the formulation.
• Severe hepatic impairment.

Common side effects

• Headache
• Nausea
• Fatigue
• Diarrhea
• Lactic acidosis

Counselling Points

• Take the medication exactly as prescribed.
• Do not skip doses to prevent the development of resistance.
• Inform healthcare provider of any other medications being taken.
• Report any signs of lactic acidosis, such as unusual muscle pain, difficulty breathing, or stomach pain.