Midazolam 50 Mg/10 Ml Solution
PDF Leaflet Revision Date: 13 August 2025
Clinical Summary
Quick overview from the medicine insert
Indication
Conscious sedation, premedication, induction, and maintenance of anesthesia.
Dosage (summary)
Adults < 60 years: 2.5 mg IV; Adults u2265 60 years: 1-1.5 mg IV.
Onset of Action / Duration
Onset: 2 mins, Duration: 1.5-2.5 hours
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Not recommended in pregnancy; excreted in breast milk.
Key Drug Interactions
- CYP3A4 inhibitors (e.g., ketoconazole)
- CYP3A4 inducers (e.g., rifampicin)
- Opioids
Contraindications
- Hypersensitivity to midazolam
- Severe hepatic impairment
- Myasthenia gravis
- Severe respiratory failure
Common side effects
- Drowsiness
- Respiratory depression
- Hypotension
Counselling Points
- Avoid driving for 12 hours post-administration
- Inform about potential sedation effects
- Gradual dose reduction recommended after long-term use
Serious warnings
- Risk of respiratory depression
- Amnesia may occur
- Monitor vital signs in high-risk patients
Important Disclaimer
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Clinical Particulars
Section 4 of the official insert — extracted exactly as issued, no alterations
