Natpem 100, 500 & 1000 100 mg, 500 mg, 1000 mg Concentrate for solution for infusion
PDF Leaflet Revision Date: 20 June 2023
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of malignant pleural mesothelioma and non-small cell lung cancer.
Dosage (summary)
500 mg/mu00b2 IV infusion over 10 mins on day 1 of each 21-day cycle.
Special Populations
- Renal impairment
- Hepatic impairment
- Elderly
Pregnancy & Breastfeeding
Not recommended in pregnancy; may cause birth defects. Discontinue breastfeeding during therapy.
Key Drug Interactions
- Nephrotoxic agents
- NSAIDs
- Live vaccines
Contraindications
- Hypersensitivity to pemetrexed
- Concomitant yellow fever vaccine
Common side effects
- Neutropenia
- Fatigue
- Nausea
- Vomiting
- Rash
Counselling Points
- Take folic acid and vitamin B12 as prophylaxis
- Avoid pregnancy during treatment
- Monitor for signs of infection
Serious warnings
- Myelosuppression
- Risk of serious renal events
- Potential for infertility
Important Disclaimer
The Natpem 100, 500 & 1000 100 mg, 500 mg, 1000 mg Concentrate for solution for infusion professional information leaflet below is the property of Adcock Ingram and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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