Pentasa 500 Mg 500 mg Tablets
PDF Leaflet Revision Date: 7 January 2026
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of mild to moderate ulcerative colitis.
Dosage (summary)
Adults: Up to 4 g once daily for active disease; 2 g once daily for maintenance.
Special Populations
- Elderly
- Children 6-18 years
Pregnancy & Breastfeeding
Use with caution; limited data show no increase in congenital malformations.
Key Drug Interactions
- Increased risk of blood dyscrasia with azathioprine
- May decrease warfarin effect
Contraindications
- Hypersensitivity to mesalazine
- Severe liver impairment
- Severe renal impairment (GFR < 30 mL/min)
Common side effects
- Diarrhoea
- Nausea
- Abdominal pain
- Headache
- Rash
Counselling Points
- Do not crush or chew tablets
- Report any signs of hypersensitivity
- Ensure adequate fluid intake
Serious warnings
- Severe cutaneous adverse reactions
- Monitor renal function
- Risk of blood dyscrasias
Important Disclaimer
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