Rayzon 5ml. 40mg Powder and Solvent for Solution for Injection
PDF Leaflet Revision Date: 15 May 2015
Clinical Summary
Quick overview from the medicine insert
Indication
Short term management of post-operative pain.
Dosage (summary)
Initial 40 mg IV/IM, then 20-40 mg every 6-12 hours, max 80 mg/day.
Onset of Action / Duration
Onset: 7-14 mins, Duration: 7-24 hours.
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Safety not established in pregnancy and lactation.
Key Drug Interactions
- Aspirin
- ACE-inhibitors
- Ciclosporin or tacrolimus
- Diuretics
- Fluconazole
- Lithium
- Warfarin
Contraindications
- Hypersensitivity to active substance
- Severe hepatic impairment
- Severe renal impairment
- CABG surgery
- Pregnancy and lactation
- Children under 18
Common side effects
- Post-operative anaemia
- Hypokalaemia
- Dizziness
- Bradycardia
- Hypotension
- Pruritus
- Back pain
Counselling Points
- Transition to oral therapy as soon as possible.
- Monitor for signs of hypersensitivity.
- Use the lowest effective dose for the shortest duration.
- Caution in patients with cardiovascular risk factors.
Serious warnings
- Increased risk of cardiovascular events
- Gastrointestinal perforations
- Serious skin reactions
- Fluid retention and oedema
Important Disclaimer
The Rayzon 5ml. 40mg Powder and Solvent for Solution for Injection professional information leaflet below is the property of Pfizer and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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