Parecoxib 40 Macleods 40 mg Powder for solution for injection
PDF Leaflet Revision Date: 09 September 2025
Clinical Summary
Quick overview from the medicine insert
Indication
Short-term management of post-operative pain.
Dosage (summary)
Initial 40 mg IV/IM, then 20-40 mg every 6-12 hours, max 80 mg/day.
Onset of Action / Duration
Onset: 7-14 mins, Duration: 7-24 hours.
Special Populations
- Elderly
- Hepatic impairment
- Renal impairment
Pregnancy & Breastfeeding
Contraindicated in pregnancy and lactation.
Key Drug Interactions
- Fluconazole
- Ketoconazole
- Warfarin
- ACE inhibitors
- Lithium
Contraindications
- Hypersensitivity to parecoxib
- Severe hepatic impairment
- Severe renal impairment
- CABG surgery
- History of gastrointestinal bleeding
- Pregnancy and lactation
- Children under 18
Common side effects
- Nausea
- Hypotension
- Dizziness
- Pruritus
Counselling Points
- Monitor for signs of hypersensitivity.
- Avoid use in patients with cardiovascular risk.
- Transition to oral therapy as soon as possible.
Serious warnings
- Increased cardiovascular risk
- Gastrointestinal complications
- Serious skin reactions
Important Disclaimer
The Parecoxib 40 Macleods 40 mg Powder for solution for injection professional information leaflet below is the property of Abex Pharmaceutica and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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