Retrovir Iv 200 mg/20 mL Infusion
PDF Leaflet Revision Date: 1 November 2023
Clinical Summary
Quick overview from the medicine insert
Indication
Short-term management of serious HIV infections; reduces maternal-foetal transmission in pregnancy.
Dosage (summary)
1.9 mg/kg every 4 hours (800 mg/day) for adults; adjust for haematological toxicity.
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Use in pregnancy to reduce HIV transmission; not recommended in first trimester.
Key Drug Interactions
- Stavudine (avoid combination)
- Clarithromycin (separate administration)
- Probenecid (increases zidovudine levels)
Contraindications
- Hypersensitivity to zidovudine
- Low neutrophil count (<0.75 x 10^9/L)
- Low haemoglobin (<7.5 g/dL)
Common side effects
- Anaemia
- Neutropenia
- Nausea
- Dizziness
Counselling Points
- Monitor for haematological toxicity
- Avoid breastfeeding
- Report any unusual symptoms immediately
Serious warnings
- Lactic acidosis risk
- Mitochondrial dysfunction
- Pancreatitis risk
Important Disclaimer
The Retrovir Iv 200 mg/20 mL Infusion professional information leaflet below is the property of Glaxosmithkline South Africa and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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