Vcide 200 Iv 200mg POWDER FOR SOLUTION FOR INFUSION
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of invasive aspergillosis and serious fungal infections.
Dosage (summary)
Loading: 6 mg/kg IV every 12 hours for 24 hours; Maintenance: 3-4 mg/kg IV every 12 hours.
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Contraindicated in pregnancy; breastfeeding not recommended during treatment.
Key Drug Interactions
- CYP3A4 substrates
- Rifampicin
- Carbamazepine
- Phenobarbital
- Efavirenz
Contraindications
- Hypersensitivity to voriconazole
- Severe hepatic impairment
- Prolonged QT syndrome
Common side effects
- Visual impairment
- Nausea
- Vomiting
- Rash
- Liver function test abnormal
Counselling Points
- Avoid sun exposure
- Monitor for visual disturbances
- Use effective contraception in women of childbearing potential
Serious warnings
- QTc prolongation
- Hepatic toxicity
- Severe cutaneous adverse reactions
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