Xarelto 10mg Tablet
PDF Leaflet Revision Date: 12 May 2023
Clinical Summary
Quick overview from the medicine insert
Indication
Prevention of venous thromboembolism (VTE) in major orthopaedic surgery.
Dosage (summary)
10 mg once daily, starting 6-10 hours post-surgery.
Onset of Action / Duration
Onset: 2-4 hours, Duration: 5-13 hours
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Contraindicated in pregnancy; use caution in lactation.
Key Drug Interactions
- Strong CYP 3A4 inhibitors (e.g., ketoconazole, ritonavir)
- NSAIDs
- Antithrombotics
Contraindications
- Hypersensitivity to rivaroxaban
- Active bleeding
- Significant hepatic disease
- Pregnancy and lactation
Common side effects
- Anaemia
- Nausea
- Dizziness
- Haemorrhage
Counselling Points
- Monitor for signs of bleeding
- Take with or without food
- Use effective contraception in women of childbearing potential
Serious warnings
- Increased bleeding risk in certain conditions
- Caution in renal impairment
- Risk of spinal haematoma with neuraxial anaesthesia
Important Disclaimer
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