Zinacef 250mg, 750mg & 1.5g Injection
PDF Leaflet Revision Date: 28 September 2000
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of infections caused by susceptible organisms.
Dosage (summary)
Adults: 1.5 to 6 g/day; 750 mg three times daily for mild infections, 1.5 g three times daily for severe infections.
Onset of Action / Duration
Onset: 30-45 mins, Duration: ~70 mins
Special Populations
- Renal impairment
Pregnancy & Breastfeeding
Safety in pregnancy and lactation not established.
Key Drug Interactions
- Probenecid may elevate serum levels
- Avoid furosemide due to nephrotoxicity risk
Contraindications
- Hypersensitivity to cephalosporins
Common side effects
- Rashes
- Thrombophlebitis
- Gastrointestinal disturbance
- Candida intertrigo
Counselling Points
- Report any allergic reactions
- Monitor for loose stools
- Do not use with other medications simultaneously
Serious warnings
- Monitor renal function in patients with renal impairment
- Risk of antibiotic colitis with prolonged use
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