Zyprexa 2.5mg. 5mg. 10mg, 10mg Tablet, Injection
Clinical Summary
Quick overview from the medicine insert
Indication
Management of psychotic disorders and acute mania.
Dosage (summary)
Initial dose 5-10 mg/day, target 10 mg/day; IM 10 mg as needed.
Onset of Action / Duration
Onset: 5-8 hours, Duration: 24 hours
Special Populations
- Elderly
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Safety not established during pregnancy and lactation.
Key Drug Interactions
- CNS depressants
- Levodopa
- Antihypertensives
Contraindications
- Hypersensitivity
- Narrow-angle glaucoma
Common side effects
- Weight gain
- Somnolence
- Orthostatic hypotension
- Dry mouth
Counselling Points
- Monitor for weight gain
- Avoid alcohol
- Caution with driving
- Gradual discontinuation recommended
Serious warnings
- Neuroleptic malignant syndrome
- Seizures
- Tardive dyskinesia
- Hyperglycemia
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