Cymbalta 30mg. 60mg Capsule
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of depression and Diabetic Peripheral Neuropathic Pain.
Dosage (summary)
60 mg once daily; initial dose 30 mg for renal/hepatic impairment.
Onset of Action / Duration
Onset: 2-4 weeks, Duration: Not specified.
Special Populations
- Renal impairment
- Hepatic impairment
- Elderly
Pregnancy & Breastfeeding
Not recommended during pregnancy; not safe for breastfeeding.
Key Drug Interactions
- MAOIs
- CYP1A2 inhibitors
- CYP2D6 inhibitors
- Serotonergic medicines
Contraindications
- Hypersensitivity to duloxetine
- Severe hepatic impairment
- Advanced renal impairment
- Concomitant MAOIs
- Patients under 18 years
Common side effects
- Nausea
- Headache
- Dry mouth
- Somnolence
- Dizziness
Counselling Points
- Avoid abrupt discontinuation
- Monitor for suicidal thoughts
- Caution with alcohol
- Report any distressing thoughts
Serious warnings
- Risk of suicide
- Serotonin syndrome
- Increased blood pressure
- Hyponatraemia
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