Zyvoxid
PDF Leaflet Revision Date: 24 February 2023
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of infections caused by susceptible Gram-positive microorganisms.
Dosage (summary)
600 mg IV or orally every 12 hours for adults; 10 mg/kg IV or orally every 8 hours for children.
Special Populations
- Elderly patients
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Contraindicated in pregnancy and lactation; safety not established.
Key Drug Interactions
- Monoamine oxidase inhibitors
- Serotonergic medications
- Sympathomimetics
Contraindications
- Hypersensitivity to linezolid
- Uncontrolled hypertension
- Carcinoid syndrome
Common side effects
- Headache
- Nausea
- Diarrhoea
- Abdominal pain
- Metallic taste
Counselling Points
- Monitor for signs of serotonin syndrome
- Report any visual changes
- Avoid tyramine-rich foods
Serious warnings
- Reversible myelosuppression
- Pseudomembranous colitis
- Optic neuropathy
- Lactic acidosis
Important Disclaimer
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