Bupivacaine Hcl 0,5 % Spinal (4 Ml) Fresenius 1 ml Solution for injection.
PDF Leaflet Revision Date: 25 May 2023
Clinical Summary
Quick overview from the medicine insert
Indication
Induction of spinal anaesthesia.
Dosage (summary)
10 to 20 mg (2 to 4 ml) for adults; smaller doses for elderly and debilitated patients.
Onset of Action / Duration
Onset: 15 mins, Duration: up to 8 hours
Special Populations
- Elderly
- Debilitated patients
- Patients with cardiac disease
- Hepatic impairment
Pregnancy & Breastfeeding
Use with caution; may cause fetal bradycardia and is distributed in breast milk.
Key Drug Interactions
- Cimetidine may decrease clearance
- Amiodarone may have additive cardiac effects
Contraindications
- Hypersensitivity to bupivacaine
- Active CNS disease
- Spinal stenosis
- Coagulation disorders
Common side effects
- Hypotension
- Bradycardia
- Nausea
- Dizziness
Counselling Points
- Ensure resuscitation equipment is available
- Monitor for signs of toxicity
- Avoid fast bolus injection
Serious warnings
- Risk of systemic toxicity
- Cardiac arrest may occur
- Increased risk in elderly and late pregnancy
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