Colocam 40mg. 100mg. 300mg. 500mg: 20mg / ml Infusion
PDF Leaflet Revision Date: 30 September 2016
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of advanced colorectal cancer.
Dosage (summary)
350 mg/mu00b2 IV every 3 weeks; 80 mg/mu00b2 weekly or 180 mg/mu00b2 every 2 weeks in combination with 5-FU and folinic acid.
Onset of Action / Duration
Onset: 5 days for delayed diarrhea.
Special Populations
- Elderly
- Impaired hepatic function
Pregnancy & Breastfeeding
Contraindicated in pregnancy and lactation.
Key Drug Interactions
- St. John's Wort
- CYP3A4 inducers/inhibitors
- Live vaccines
Contraindications
- Severe hypersensitivity
- Chronic inflammatory bowel disease
- Bilirubin > 1.5 times ULN
- Severe bone marrow failure
- WHO performance status > 2
Common side effects
- Diarrhea
- Nausea
- Vomiting
- Neutropenia
- Fatigue
Counselling Points
- Hydration and anti-diarrheal therapy are crucial
- Avoid pregnancy during and 3 months post-treatment
- Report severe diarrhea immediately
Serious warnings
- Risk of delayed diarrhea
- Monitor for severe neutropenia
- Use in specialized units only
Important Disclaimer
The Colocam 40mg. 100mg. 300mg. 500mg: 20mg / ml Infusion professional information leaflet below is the property of Equity Pharmaceuticals and is provided on Medinsert exactly as issued, with no.. alterations or editorial changes. We make every effort to keep content current by updating documents as soon as new versions become available. Medinsert serves as a trusted access point for healthcare professionals, but does not replace official sources or clinical judgement. For more details, please read our full disclaimer. read more>>
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