Zantipres Co Tablet
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of mild to moderate essential hypertension.
Dosage (summary)
One tablet once daily for adults; not recommended for patients with volume or salt depletion.
Onset of Action / Duration
Onset: 2 hours, Duration: 6-12 hours
Special Populations
- Elderly patients
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Contraindicated in pregnancy and breastfeeding.
Key Drug Interactions
- Concomitant use with sacubitril/valsartan
- Potassium-sparing diuretics
- Lithium
Contraindications
- Hypersensitivity to zofenopril or hydrochlorothiazide
- History of angioedema
- Severe renal impairment
- Severe hepatic impairment
Common side effects
- Dizziness
- Cough
- Hypotension
- Hyperkalaemia
Counselling Points
- Monitor blood pressure regularly
- Report any signs of angioedema
- Avoid potassium supplements
Serious warnings
- Risk of severe hypotension
- Angioedema
- Neutropenia
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