Noxafil 300 Mg Concentrate For Solution For Infusion 300 mg Concentrate for solution for infusion.
PDF Leaflet Revision Date: 17 September 2024
Clinical Summary
Quick overview from the medicine insert
Indication
Prophylaxis and treatment of invasive fungal infections in high-risk patients.
Dosage (summary)
Loading dose: 300 mg twice daily on Day 1, then 300 mg once daily.
Special Populations
- Renal impairment
- Hepatic impairment
- Elderly
Pregnancy & Breastfeeding
Contraindicated in pregnancy and breastfeeding due to potential risks.
Key Drug Interactions
- CYP3A4 substrates
- Ergot alkaloids
- Benzodiazepines metabolised by CYP3A4
Contraindications
- Hypersensitivity to posaconazole
- Co-administration with ergot alkaloids
- Co-administration with certain CYP3A4 substrates
Common side effects
- Diarrhoea
- Nausea
- Rash
- Hypokalaemia
- Vomiting
Counselling Points
- Monitor for signs of hypersensitivity.
- Avoid use with certain medications.
- Report any unusual symptoms.
Serious warnings
- Hepatic toxicity
- QT prolongation
- Renal impairment monitoring
Important Disclaimer
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