Posaconazole Tablet 100 Mg-Msd 100 mg Tablet
PDF Leaflet Revision Date: 14 October 2024
Clinical Summary
Quick overview from the medicine insert
Indication
Treatment of refractory fungal infections and prophylaxis in high-risk patients.
Dosage (summary)
Loading dose of 300 mg twice daily on Day 1, then 300 mg once daily.
Special Populations
- Renal impairment
- Hepatic impairment
Pregnancy & Breastfeeding
Contraindicated in pregnancy and breastfeeding due to potential risks.
Key Drug Interactions
- CYP3A4 substrates
- Ergot alkaloids
- HMG-CoA reductase inhibitors
Contraindications
- Hypersensitivity to posaconazole
Common side effects
- Nausea
- Diarrhoea
- Dizziness
- Elevated liver function tests
Counselling Points
- Take without regard to food
- Monitor for liver function
- Avoid in pregnancy and breastfeeding
Serious warnings
- QT prolongation
- Hepatic toxicity
- Vincristine toxicity
Important Disclaimer
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